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 Glyciphosphoramide

The antitumor activity of oral glyciphosphoramide  was demonstrated in tumor-bearing animals (mice, rats, and dogs). In mice, the LD50 for oral and i.p. I were 580 and 360 mg/kg, resp. The max. tolerated dose of I in dogs was 20 mg/kg/day. In normal rats, 14C-radioactivity in blood reached its peak 8 h after oral administration of I-14C. The tissue distribution of I-14C in normal and tumor-bearing rats was similar, the radioactivity being highest in liver, kidney, and gastrointestinal tract and tumor tissue. The cumulative excretion of 14C-radioactivity in urine and feces was 32.54% within 96 h. see: Zhongguo Yixue Kexueyuan Xuebao (1984), 6(5), 334-7.   

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16. Wang Z Y Clinical evaluation of glyciphosphoramide used alone and in combination with other drugs. Zhonghua zhong liu za zhi [Chinese journal of oncology] (1984), 6(5), 379-81.

17. Sun Y Clinical phase II trial of a new antineoplastic drug, glyciphosphoramide (GPM). Zhonghua zhong liu za zhi [Chinese journal of oncology] (1984), 6(5), 375-8. 

18. Sun Y Clinical phase I trial of a new anti-neoplastic drug--glyciphosphoramide. Zhonghua zhong liu za zhi [Chinese journal of oncology] (1984), 6(4), 293-5. 

19. Guo J Y; Huang L; Tian S H; Zhao Q R Synthesis of the 14C labelled anticancer agent: N,N-bis(beta-chloroethyl)-N',N"-di(carboethoxy-[14C] methyl)-phosphorotriamide. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae (1984), 6(4), 295-7. 

20. Sun Y Clinical phase II trial of a new antineoplastic drug--glyciphosphoramide. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae (1984), 6(4), 273-6.