|
Back to products
Browse products
Approved anticancer agents
Anticancer agents in trials
Anticancer molecular libraries
Other drug agents
Drug intermediates
Bio-reagents and biochemicals
|
MedKoo product information:
Dromostanolone propionate
|
MedKoo Code#: 100284
|
|
Name:
Dromostanolone
propionate
|
|
CAS#: 521-12-0
Synonym: masteril,
masteron, 17b-Hydroxy-2a-methyl-5a-androstan-3-one propionate.
IUPAC/Chemical name:
(2R,5S,8R,9S,10S,13S,14S,17S)-2,10,13-trimethyl-3-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl
propionate
|
|
Chemical structure:
|
Theoretical analysis
:
|
|

|
Chemical Formula: C23H36O3
Exact Mass: 360.26645
Molecular Weight: 360.53
m/z: 360.26645 (100.0%), 361.26980 (24.9%),
362.27315 (3.0%)
Elemental Analysis: C, 76.62; H, 10.06; O,
13.31
|
|
Availability and price:
For quotation, question, and order, please send email to
sales@medkoo.com to describe your needs. A representative
will respond your email shortly. We offer significant discount
for larger quantity order.
|
|
Quality control
data:
Product will be shipped with
supporting analytical data.
|
|
Information about this agent
|
Masteron (dromostanolone propionate, also known as drostanolone
propionate) had formerly been a rare drug in the United States and
was enjoyed principally by our European friends. This was due to
never been produced in great quantity by Syntex and never being
marketed in the United States. It presently is available from
various non-pharmaceutical suppliers. Many also make home-prepared
injectables from powder provided by various sources.
Masteron is unaffected by the aromatase and 5alpha-reductase enzymes
and therefore there are no issues with estrogen or with potentiation
(increase of effect) in tissues such as the skin and prostate. In
fact, Masteron is somewhat anti-estrogenic due to competing with
estradiol at the estrogen receptor, while not itself activating the
receptor, and perhaps by likewise competing with testosterone for
the binding site of the aromatase enzyme, thus reducing conversion.
Dromostanolone propionate is the chemical name of active ingredient
in Masteron. Masteron was a registered trademark of Sarva-Syntex in
Belgium and/or other countries prior to cancellation. from
http://www.mesomorphosis.com/steroid-profiles/masteron.htm
Masteron (dromostanolone propionate or drostanolone
propionate), is a popular steroid among competitive bodybuilders. It is
commonly used in contest preparation for many reasons. To begin with,
dromostanolone propionate is a derivative of DHT (dihydrotestosterone),
and therefore, it will not aromatize into estrogen. Competing
bodybuilders find this extremely beneficial because aromatization
typically causes excess water retention which may give the muscles a
smooth appearance. Another advantage of Masteron is its strong
androgenic component. The androgenic effect of this steroid can cause a
noticeable improvement in muscle density and hardness which can help the
bodybuilder obtain the “ripped” look if his bodyfat percentage is low
enough. The androgenic effect is also crucial because it helps to
provide sufficient “kick” or “drive” for intense training when an
athlete has lowered his caloric intake for contest preparation. Masteron
can also be used successfully by bodybuilders preparing for a
drug-tested show. The substance dromostanolone propionate is fast acting
and quickly broken down. The athlete can therefore use Masteron up to
about ten days before a drug test. The average dosage of Masteron is 100
mg injected every other day. It is best to inject Masteron every 2-3
days because it has a short duration of effect. Popular steroids stacked
with Masteron include Parabolan (trenbolone hexahydrobencylcarbonate),
Winstrol (stanozolol), and oxandrolone. from
http://www.steroids.ro/steroid-profiles/masteron.html.
1: Marinov L, Tsekova V, Koĭnov K, Velikova M,
Micheva D. [Drostanolone propionate (masteril) in disseminated breast
cancer in women. Immediate results]. Khirurgiia (Sofiia).
1987;40(6):80-6. Bulgarian. PubMed PMID: 2830431.
2: Iwasa Z, Saeki Y, Matsunami N, Yasutomi M. [Diagnosis of minimal
breast cancer by diagnostic hormonal treatment]. Gan No Rinsho. 1986
Apr;32(4):345-8. Japanese. PubMed PMID: 2940386.
3: Fujita H, Teller MN, Green S, Kreis W. Effects of 5-fluorouracil and
2 alpha-methyldihydrotestosterone propionate on the growth of human
breast carcinoma MCF-7 in vitro. Eur J Cancer Clin Oncol. 1983
Sep;19(9):1231-7. PubMed PMID: 6688585.
4: Teller MN, Stock CC, Bowie M, Chou TC, Budinger JM. Therapy of
7,12-dimethylbenz(a)anthracene-induced rat mammary carcinomas with
combinations of 5-fluorouracil and 2 alpha-methyldihydrotestosterone
propionate. Cancer Res. 1982 Nov;42(11):4408-12. PubMed PMID: 6812946.
5: Clavel B, Cappelaere JP, Guerin J, Klein T, Pommatau E, Berlie J.
[Management of advanced breast cancer in post-menopausal women. A
comparative trial of hormonal therapy, chemotherapy, and a combination
of both]. Sem Hop. 1982 Sep 23;58(34):1919-23. French. PubMed PMID:
6293073.
6: Pieńkowska F, Paszko Z, Padzik H, Dziadek T. [Relationship between
the effects of endocrinological treatment of breast cancer and the
presence of estrogen receptor in the cancer tissue]. Nowotwory. 1980
Jan-Mar;30(1):25-35. Polish. PubMed PMID: 6893078.
7: Trams G. Effect of drostanolone propionate on the binding of
oestradiol and dihydrotestosterone by normal and malignant target
tissues. Eur J Cancer. 1977 Feb;13(2):149-53. PubMed PMID: 576855.
8: Chowdhury MS, Banks AJ, Bond WH, Jones WG, Ward HW. A comparison of
drostanolone propionate (Masteril) and nandrolone decanoate (Deca-durabolin)
in the treatment of breast carcinoma. Clin Oncol. 1976 Sep;2(3):203-6.
PubMed PMID: 1036981.
9: Bennett MB, Helman P, Palmer P. Hormonal therapy of breast cancer
with special reference to Masteril therapy. S Afr Med J. 1975 Nov
15;49(49):2036-40. PubMed PMID: 1242823.
10: von Lieven H, Büll U. [The treatment of metastasising mammary
carcinoma with drostanolone propionate (masterid) (author's transl)].
MMW Munch Med Wochenschr. 1974 Nov 22;116(47):2043-6. German. PubMed
PMID: 4216810.
11: Drings P, Fritsch H, Schmidt-Hermes HJ. [Experiences with
Drostanolone-Propionate (Masterid) in metastasizing breast carcinoma].
Ther Ggw. 1972 Apr;111(4):547-8 passim. German. PubMed PMID: 5029717.
12: Seay DG, Bradshaw JD, Nicol NT. Clinical experience with
dromostanolone propionate (NSC-12198) in breast carcinoma. Cancer
Chemother Rep. 1972 Feb;56(1):89-92. PubMed PMID: 5067664.
13: Nomura Y, Hattori T, Abe Y, Iguchi K. [Long-term combined
administration of dromostanolone propionate (Mastisol) and
cyclophosphamide (Endoxan) for advanced breast cancer after surgical
hormone therapy]. Gan No Rinsho. 1971 Dec;17(12):899-904. Japanese.
PubMed PMID: 5172404.
14: Van der Gugten AA. The effect of I-(morpholinomethyl)-4-phtalimido-piperidindione-2,6
and drostanolone propionate on the plasma prolactin concentration of
oestrone-treated orchidectomized R-Amsterdam rats. Eur J Cancer. 1971
Dec;7(6):581-2. PubMed PMID: 5172331.
15: Petit JC, Klein T, Rodier D. [Hormonal therapy of advanced breast
cancer with drostanolone propionate]. Bull Cancer. 1971
Oct-Dec;58(4):511-22. French. PubMed PMID: 4115657.
16: Poddig-von Riegen S, Notter G. [Treatment of disseminated mammary
carcinoma with drostanolone propionate (Masterid). Report on 22 treated
cases]. Munch Med Wochenschr. 1971 Apr 30;113(18):695-7. German. PubMed
PMID: 5108667.
17: Brown IG. Treatment of disseminated mammary carcinoma with
drostanolone propionate. Practitioner. 1970 Sep;205(227):336-7. PubMed
PMID: 5536680.
18: Heney NM. Treatment of advanced breast carcinoma with drostanolone
propionate. A case report. Bristol Med Chir J. 1970 Jul;85(315):75-6.
PubMed PMID: 5536155.
19: Mückter H, Frankus E, Moré E. Experimental investigations with 1-(morpholinomethyl)-4-phthalimido-piperidindione-2,
6 and drostanolone propionate in dimethylbenz-anthracene-induced tumors
of Sprague-Dawley rats. Cancer Res. 1970 Feb;30(2):430-8. PubMed PMID:
5458973.
20: Takeuchi S, Yoshida M. [Clinical study of dromostanolone propionate
for mastopathy--with special reference to screening of breast cancer].
Saishin Igaku. 1967 May;22(5):1049-54. Japanese. PubMed PMID: 5630583.
|
Contact MedKoo:
Email:
sales@medkoo.com
(Keyword; CAS#; MedKoo code#)
|