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 Carboquone

Carboquone is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.

  1: Bolboacă SD, Jäntschi L. Comparison of quantitative structure-activity relationship model performances on carboquinone derivatives. ScientificWorldJournal. 2009 Oct 14;9:1148-66. PubMed PMID: 19838601.

2: Suzuki Y, Takagi R, Kawasaki I, Matsudaira T, Yanagisawa H, Shimizu H. The micronucleus test and erythropoiesis: effects of cyclic adenosine monophosphate (cAMP) on micronucleus formation. Mutat Res. 2008 Aug-Sep;655(1-2):47-51. PubMed PMID: 18621143.

3: Morimoto K, Koh M. [Postoperative changes in serum lipid levels of breast cancer and adjuvant chemotherapy]. Gan To Kagaku Ryoho. 2004 Oct;31(10):1517-24. Japanese. PubMed PMID: 15508443.

4: Kawakami J, Hoshi K, Ishiyama A, Miyagishima S, Sato K. Application of a self-organizing map to quantitative structure-activity relationship analysis of carboquinone and benzodiazepine. Chem Pharm Bull (Tokyo). 2004 Jun;52(6):751-5. PubMed PMID: 15187400.

5: Morimoto K, Koh M. Postoperative adjuvant use of carmofur for early breast cancer. Osaka City Med J. 2003 Dec;49(2):77-83. PubMed PMID: 15179836.

6: Hargreaves RH, Hartley JA, Butler J. Mechanisms of action of quinone-containing alkylating agents: DNA alkylation by aziridinylquinones. Front Biosci. 2000 Nov 1;5:E172-80. Review. PubMed PMID: 11056081.

7: Begleiter A. Clinical applications of quinone-containing alkylating agents. Front Biosci. 2000 Nov 1;5:E153-71. Review. PubMed PMID: 11056078.

8: Tabata M, Imagawa S, Tarumoto T, Ohmine K, Hatake K, Miura Y, Ozawa K. Essential thrombocythemia transformed to acute myelogenous leukemia with t(3;17)(p24; q12), del(5)(q13q34) after treatment with carboquone and hydroxyurea. Jpn J Clin Oncol. 2000 Jul;30(7):310-2. PubMed PMID: 11007164.

9: Nio Y, Tamura K, Kan N, Inamoto T, Ohgaki K, Kodama H. Anticancer chemosensitivity profiles of human breast cancer cells assessed by in vitro DNA synthesis inhibition assay. Anticancer Res. 2000 Mar-Apr;20(2B):1237-44. PubMed PMID: 10810427.

10: Higuchi T, Oba R, Endo M, Harada H, Mori H, Niikura H, Omine M, Fujita K. Transition of polycythemia vera to chronic neutrophilic leukemia. Leuk Lymphoma. 1999 Mar;33(1-2):203-6. Review. PubMed PMID: 10194140.

11: Gough JD, Hall LH. Modeling antileukemic activity of carboquinones with electrotopological state and chi indices. J Chem Inf Comput Sci. 1999 Mar-Apr;39(2):356-61. PubMed PMID: 10192947.

12: Naoe Y, Inami M, Kawamura I, Nishigaki F, Tsujimoto S, Matsumoto S, Manda T, Shimomura K. Cytotoxic mechanisms of FK317, a new class of bioreductive agent with potent antitumor activity. Jpn J Cancer Res. 1998 Jun;89(6):666-72. PubMed PMID: 9703365.

13: Kawabata K, Nio Y, Imamura M, Fukumoto M. Anticancer chemosensitivity and growth rate of freshly separated human colorectal cancer cells assessed by in vitro DNA synthesis inhibition assay. Anticancer Res. 1998 May-Jun;18(3A):1633-40. PubMed PMID: 9673382.

14: Kawabata K, Nio Y, Imamura M. 5-Fluorouracil + cisplatin + mitomycin C is a relatively most effective combination against xenograft lines of human colorectal cancer. Anticancer Drugs. 1997 Sep;8(8):790-6. PubMed PMID: 9396624.

15: Takeuchi H, Baba H, Inutsuka S, Maehara Y, Sugimachi K. Potentiation of the cytotoxicity of carboquone by flavone acetic acid combined with hyperthermia. Anticancer Drugs. 1997 Sep;8(8):778-83. PubMed PMID: 9396622.

16: Takenaka T, Maruyama K, Kinoshita T, Sasako M, Sano T, Katai H, Matsuno Y. A prospective study of surgery and adjuvant chemotherapy for primary gastric lymphoma stage II. Br J Cancer. 1997;76(11):1484-8. PubMed PMID: 9400946; PubMed Central PMCID: PMC2228181.

17: Morgan WA, Prins B, Koster AS. Relationship between acute toxicity of (bis)aziridinylbenzoquinones and cellular pyridine nucleotides. Arch Toxicol. 1997;71(9):582-7. PubMed PMID: 9285041.

18: Sakata Y, Takemori H, Suzuki H. [Chemotherapy for pancreatic cancer]. Gan To Kagaku Ryoho. 1996 Oct;23(12):1647-50. Review. Japanese. PubMed PMID: 8886035.

19: Matano S, Nakamura S, Kobayashi K, Kaya H, Yoshida T, Sugimoto T. [Low-dose combination cytarabine and etoposide for myeloid crisis transformed from unclassified chronic myeloproliferative disorder]. Gan To Kagaku Ryoho. 1996 Jul;23(8):1055-8. Japanese. PubMed PMID: 8687221.

20: Ito H. [Experimental study and clinical application of a new combination chemotherapy with cis-platinum, adriamycin and carboquone in patients with advanced prostate cancer]. Nippon Ika Daigaku Zasshi. 1995 Oct;62(5):456-68. Japanese. PubMed PMID: 7499463.

21: Mäenpää JU, Heinonen E, Hinkka SM, Karnani P, Klemi PJ, Korpijaakko TA, Kuoppala TA, Laine AM, Lähde MA, Nuoranne EK, et al. The subrenal capsule assay in selecting chemotherapy for ovarian cancer: a prospective randomized trial. Gynecol Oncol. 1995 Jun;57(3):294-8. PubMed PMID: 7774832.

22: Shibata K, Kasahara K, Bando T, Nakatsumi Y, Fujimura M, Tsuruo T, Matsuda T. Establishment and characterization of non-small cell lung cancer cell lines resistant to mitomycin C under aerobic conditions. Jpn J Cancer Res. 1995 May;86(5):460-9. PubMed PMID: 7790319.

23: Higuchi T, Okada S, Mori H, Niikura H, Omine M, Terada H. Leukemic transformation of polycythemia vera and essential thrombocythemia possibly associated with an alkylating agent. Cancer. 1995 Jan 15;75(2):471-7. PubMed PMID: 7812918.

24: Miyagi M, Soda T, Nakashima T. [Flow cytometric DNA analysis and chemosensitivity in squamous cell carcinoma of the head and neck]. Nippon Jibiinkoka Gakkai Kaiho. 1994 Dec;97(12):2247-58. Japanese. PubMed PMID: 7861297.

25: Masai Y, Nio Y, Tsubono M, Tseng CC, Kawabata K, Hayashi H, Ishigami S, Imamura M. Anticancer chemosensitivity profile of freshly separated human pancreatic cancer cells assessed by DNA synthesis inhibition assay. J Surg Oncol. 1994 Oct;57(2):97-104. PubMed PMID: 7934070.

26: Okuyama T, Maehara Y, Endo K, Baba H, Adachi Y, Kuwano M, Sugimachi K. Expression of glutathione S-transferase-pi and sensitivity of human gastric cancer cells to cisplatin. Cancer. 1994 Aug 15;74(4):1230-6. PubMed PMID: 8055443.

27: Emi Y, Maehara Y, Kusumoto T, Baba H, Takahashi I, Yoshida M, Sugimachi K. Hydralazine combined with hyperthermia enhances the effects of carboquone. Oncology. 1994 Jul-Aug;51(4):339-43. PubMed PMID: 8208517.

28: Baba H, Takeuchi H, Inutsuka S, Yamamoto M, Endo K, Ohno S, Maehara Y, Sugimachi K. Clinical value of SDI test for predicting effect of postoperative chemotherapy for patients with gastric cancer. Semin Surg Oncol. 1994 Mar-Apr;10(2):140-4. PubMed PMID: 8052784.

29: Takeuchi H, Baba H, Inutsuka S, Takahashi I, Kusumoto H, Maehara Y, Sugimachi K. Antitumor chemosensitivity differs between clinical sarcoma and adenocarcinoma tissues. Anticancer Res. 1994 Jan-Feb;14(1A):169-71. PubMed PMID: 8166444.

30: Sampi K, Makishima M, Kuga T, Yanagawa S, Hattori M. [Intensive 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3- nitrosourea hydrochloride (ACNU) and cryopreserved autologous bone marrow transplantation]. Gan To Kagaku Ryoho. 1993 Oct;20(13):1989-93. Japanese. PubMed PMID: 8215473.

31: Yoh S, Isayama T, Yoshitake K, Johzima H, Ikari N, Ogata K. [Post-operative intra-arterial chemotherapy for high grade malignant musculoskeletal sarcoma]. Gan To Kagaku Ryoho. 1993 Aug;20(11):1682-5. Japanese. PubMed PMID: 8373248.

32: Harada Y, Katano T, Nakamura Y, Adachi Y. [A case of chronic neutrophilic leukemia associated with polycythemia vera]. Rinsho Ketsueki. 1993 Jun;34(6):738-42. Review. Japanese. PubMed PMID: 8366577.

33: Tetko IV, Luik AI, Poda GI. Applications of neural networks in structure-activity relationships of a small number of molecules. J Med Chem. 1993 Apr 2;36(7):811-4. PubMed PMID: 8464034.

34: Adachi A, Hayashi A, Hayashida R, Hattori R, Nagamatsu Y, Nasu K, Iwanaga D, Takagi K, Ono H, Kakegawa T. [Preoperative chemotherapy in patients with non-small cell lung cancer]. Gan To Kagaku Ryoho. 1993 Apr;20(5):673-5. Japanese. PubMed PMID: 8385907.

35: Ichikawa H, Aoyama T. How to see characteristics of structural parameters in QSAR analysis: descriptor mapping using neural networks. SAR QSAR Environ Res. 1993;1(2-3):115-30. PubMed PMID: 8790628.

36: Mäenpää JU, Heinonen E, Karnani P, Kauppila A, Kuoppala T, Salmi T, Sipilä P, Nieminen U. Carboquone combined with methotrexate and 5-fluorouracil for recurrent and advanced ovarian cancer. Eur J Cancer. 1993;29A(11):1633. PubMed PMID: 8217372.

37: Yonekura S, Nagao T, Arimori S. Essential thrombocythemia developing into refractory anemia and complicated by acute myeloid leukemia. Intern Med. 1992 Oct;31(10):1224-7. PubMed PMID: 1286233.

38: Takamori S, Tsushimi M, Onaka A, Nakarai I. [A case of hyperosmolar nonketotic coma occurring during chemotherapy in lung cancer]. Gan To Kagaku Ryoho. 1992 Sep;19(11):1919-22. Japanese. PubMed PMID: 1325754.

39: Yamagata M, Kanematsu T, Matsumata T, Utsunomiya T, Ikeda Y, Sugimachi K. The difference in chemosensitivity to antineoplastic agents of human hepatocellular carcinoma cells under normo-oxygenated or hypoxic conditions. Eur J Surg Oncol. 1992 Aug;18(4):379-82. PubMed PMID: 1325926.

40: Fushiki H. [Characterization of two novel cell lines established from a single human uterine cervical adenocarcinoma, and their chemosensitivities and hormonal effects on their proliferation]. Nippon Sanka Fujinka Gakkai Zasshi. 1992 Apr;44(4):397-404. Japanese. PubMed PMID: 1607768.

41: Akimoto Y, Ishiyama T, Sano M, Ueno H, Nakamaki T, Hino K, Tomoyasu S, Tsuruoka N. [Essential thrombocythemia that transformed to myelofibrosis after three years]. Rinsho Ketsueki. 1992 Apr;33(4):520-4. Japanese. PubMed PMID: 1602618.

42: Hino K, Sato S, Sakashita A, Tomoyasu S, Tsuruoka N, Koike T. [Megakaryoblastic transformation associated with disseminated intravascular coagulation in the course of polycythemia vera: a case report]. Rinsho Ketsueki. 1992 Apr;33(4):500-6. Review. Japanese. PubMed PMID: 1602615.

43: Katayama T, Masuoka H, Yoshida M, Watanabe R, Nishiwaki K, Shimada T, Kaito K, Ochiai S, Kobayashi M, Sakai O. [Successful low-dose etoposide therapy for a case of myelofibrosis with chronic myelogenous leukemia megakaryocytic predominance type]. Rinsho Ketsueki. 1992 Apr;33(4):488-93. Japanese. PubMed PMID: 1602613.

44: Sakaguchi Y, Anai H, Kohnoe S, Emi Y, Kusumoto T, Maehara Y, Sugimachi K. Resistance to anticancer drugs of well differentiated gastric adenocarcinoma with venous invasion. Eur J Surg Oncol. 1992 Apr;18(2):142-5. PubMed PMID: 1582507.

45: Sampi K, Kuga T, Makishima M, Hattori M. [Intensive carboquone and cryopreserved autologous bone marrow transplantation for relapsed malignancies]. Gan To Kagaku Ryoho. 1992 Feb;19(2):257-9. Japanese. PubMed PMID: 1736840.

46: Kusumoto H, Maehara Y, Yoshida M, Takahashi I, Anai H, Sugimachi K. Relationship between tumor histopathology and in vitro sensitivity to antitumor drugs in gastric cancer. Anticancer Drugs. 1992 Feb;3(1):33-8. PubMed PMID: 1623213.

47: Saito A, Korenaga D, Maehara Y, Baba H, Okamura T, Sugimachi K. In vitro succinate dehydrogenase chemosensitivity of gastric carcinoma--relationship to DNA content. Cancer Chemother Pharmacol. 1992;29(3):185-9. PubMed PMID: 1733550.

48: Okada J, Masuyama Y, Kondo T. An analysis of first-order release kinetics from albumin microspheres. J Microencapsul. 1992 Jan-Mar;9(1):9-18. PubMed PMID: 1613648.

49: Kusumoto T, Sakaguchi Y, Maehara Y, Nakashima T, Furusawa M, Sugimachi K. Comparison of in vitro anticancer chemosensitivity between human squamous cell carcinoma and adenocarcinoma. Oncology. 1992;49(5):343-6. PubMed PMID: 1528569.

50: Sakaguchi Y, Kohnoe S, Emi Y, Maehara Y, Kusumoto T, Sugimachi K. Cytotoxicity of mitomycin C and carboquone combined with hyperthermia against hypoxic tumor cells in vitro. Oncology. 1992;49(3):227-32. PubMed PMID: 1495751.

51: Nio Y, Tseng CC, Tsubono M, Kawabata K, Masai Y, Shiraishi T, Fukumoto M, Tobe T. Combining independently effective anticancer agents may not augment the independent antitumor effects: a study using human digestive organ cancer xenograft lines in nude mice. J Surg Oncol. 1991 Dec;48(4):252-9. PubMed PMID: 1745050.

52: Tsushima K, Sakata Y, Shiratori Y, Sakamoto J, Koeda J, Yamada Y, Soma N, Tamura K, Yoshiwara A, Soma Y, et al. [Cases of advanced cholangiocarcinoma showing partial response by the combination chemotherapy including protracted continuous infusion of 5-FU combined with intravenous administration of low-dose leucovorin and intra-arterial administration of MMC and CQ]. Gan To Kagaku Ryoho. 1991 Dec;18(15):2603-5. Japanese. PubMed PMID: 1660702.

53: Fujita H. [Clinical pharmacology of anticancer agents. (Part 1) Introduction, alkylating agents and platinum compounds]. Gan To Kagaku Ryoho. 1991 Nov;18(14):2481-7. Japanese. PubMed PMID: 1952967.

54: Okada J, Asano S, Kondo T. A new concept for interpretation of first-order release from albumin microspheres. J Microencapsul. 1991 Oct-Dec;8(4):483-96. PubMed PMID: 1798019.

55: Miyoshi Y, Okada S, Takizawa Y, Hagiwara S, Mori H, Niikura H, Terada H, Fujita K. [Acute megakaryoblastic leukemia developing 11 years after diagnosis of essential thrombocythemia]. Rinsho Ketsueki. 1991 Aug;32(8):868-73. Review. Japanese. PubMed PMID: 1942527.

56: Kusumoto T, Maehara Y, Sakaguchi Y, Kohnoe S, Emi Y, Sugimachi K. Sarcoma-180 cells and human colorectal tumor cells under in vitro hypoxic conditions are more sensitive to mitomycin C and carboquone. Eur J Surg Oncol. 1991 Aug;17(4):358-63. PubMed PMID: 1908390.

57: Ohyama S, Yonemura Y, Kinoshita K, Ninomiya I, Tugawa K, Kimura H, Miyazaki I, Tanaka M, Endo Y, Sasaki T. [Chemosensitivity test for gastric cancer by in vitro MTT assay]. Gan To Kagaku Ryoho. 1991 Aug;18(10):1593-7. Japanese. PubMed PMID: 1908213.

58: Ikeda K, Niwa N, Oka F, Ito H, Abe H, Nakagami Y. [A case of advanced prostatic cancer presenting as inguinal mass]. Hinyokika Kiyo. 1991 Jul;37(7):765-7. Japanese. PubMed PMID: 1927782.

59: Kohnoe S, Emi Y, Takahashi I, Yoshida M, Maehara Y, Sugimachi K. Hypoxia and acidity increase the cytotoxicity of mitomycin C and carboquone to human tumor cells in vitro. Anticancer Res. 1991 Jul-Aug;11(4):1401-4. PubMed PMID: 1746896.

60: Kido Y, Mitsudomi T, Kuwano H, Maehara Y, Sugimachi K. Different chemosensitivities of rat 3Y1 fibroblasts transformed by various agents in vitro. Anticancer Res. 1991 May-Jun;11(3):1305-8. PubMed PMID: 1888164.

61: Kohnoe S, Emi Y, Sakaguchi Y, Maehara Y, Kusumoto T, Sugimachi K. The microtiter SDI test is more advantageous than the SDI test for assessing the chemosensitivity of human tumor cells. Anticancer Drugs. 1991 Apr;2(2):145-52. PubMed PMID: 1958859.

62: Imai S, Nio Y, Shiraishi T, Manabe T, Tobe T. In vivo inhibitory effect of anticancer agents on human pancreatic cancer xenografts transplanted in nude mice. Anticancer Res. 1991 Mar-Apr;11(2):657-64. PubMed PMID: 2064319.

63: Nakayama T, Nakai Y, Tamura H, Nagano T, Shibamoto T, Ohara A, Ozawa M, Kurata A. [A case of granulosa cell tumor with unusual histologic features]. Nippon Sanka Fujinka Gakkai Zasshi. 1991 Mar;43(3):367-70. Japanese. PubMed PMID: 1904472.

64: Sato K, Horiuchi M, Yo R, Nakarai I. [A long survival case of small cell lung cancer synchronized with renal cancer]. Kyobu Geka. 1991 Mar;44(3):251-3. Japanese. PubMed PMID: 1850490.

65: Kohnoe S, Moriguchi S, Emi Y, Sakaguchi Y, Maehara Y, Ishida T, Mitsudomi T, Sugimachi K. Lung adenocarcinoma is more sensitive than gastric adenocarcinoma to anticancer drugs in vitro. Eur J Surg Oncol. 1991 Feb;17(1):47-50. PubMed PMID: 1995357.

66: Nakajima T, Masuda H, Okamoto T, Watanabe M, Yokoyama K, Yamada N, Fujimoto S, Tsukagoshi S, Taguchi T. [Cross-resistance of HO-221 and various antitumor agents in sublines of mouse leukemia]. Gan To Kagaku Ryoho. 1991 Feb;18(2):201-9. Japanese. PubMed PMID: 1899547.

67: Ueo H, Maehara Y, Saito A, Sakaguchi Y, Kohnoe S, Sugimachi K. Human colon cancer tissues are more sensitive than rectal cancer tissues to antitumor drugs in vitro. Oncology. 1991;48(2):158-61. PubMed PMID: 1997940.

68: Nakajima T, Masuda H, Okamoto T, Watanabe M, Yokoyama K, Yamada N, Fujimoto S, Tsukagoshi S, Taguchi T. Antitumor activity on murine tumors of a novel antitumor benzoylphenylurea derivative, HO-221. Cancer Chemother Pharmacol. 1991;28(5):351-6. PubMed PMID: 1914078.

69: Kanematsu T, Maehara Y, Matsumata T, Shirabe K, Akazawa K, Sugimachi K. Human hepatocellular carcinoma sensitivity to antitumor drugs assayed using the succinate dehydrogenase inhibition test. Oncology. 1991;48(1):34-8. PubMed PMID: 1846232.

70: Kondo T, Sakamoto J, Nakazato H. Alternating immunochemotherapy of advanced gastric carcinoma: a randomized comparison of carbazilquinone and PSK to carbazilquinone in patients with curative gastric resection. Biotherapy. 1991;3(4):287-95. PubMed PMID: 1786194.

71: Hasuda K, Kobayashi H, Taniguchi S, Baba T. Increased therapeutic efficacy of intra-arterial carboquone chemotherapy on a limb tumor in rats, by using an acidic vehicle adjusted with lactate. Cancer Lett. 1990 Nov 5;54(3):133-7. PubMed PMID: 2224841.

72: Miyamoto K, Fukuchi K. [The sensitivity of 1,000 human tumors to antitumor drugs using the succinate dehydrogenase inhibition (SDI) test]. Rinsho Byori. 1990 Nov;38(11):1273-8. Japanese. PubMed PMID: 2273570.

73: Yagi S, Hashiguchi K, Nakajima M, Umeki S, Hara H, Soejima R. [A case of polycythemia vera associated with idiopathic interstitial pneumonia successfully treated by alkylating agents]. Nihon Kyobu Shikkan Gakkai Zasshi. 1990 Oct;28(10):1366-71. Japanese. PubMed PMID: 2273667.

74: Nakashima T, Maehara Y, Kohnoe S, Hayashi I, Katsuta Y. Histologic differentiation and chemosensitivity of human head and neck squamous cell carcinomas. Head Neck. 1990 Sep-Oct;12(5):406-10. PubMed PMID: 2211101.

75: Aoyama T, Suzuki Y, Ichikawa H. Neural networks applied to quantitative structure-activity relationship analysis. J Med Chem. 1990 Sep;33(9):2583-90. Review. PubMed PMID: 2202830.

76: Mitsudomi T, Kaneko S, Tateishi M, Yano T, Ishida T, Kohnoe S, Maehara Y, Sugimachi K. Chemosensitivity testing of human lung cancer tissues using the succinate dehydrogenase inhibition test. Anticancer Res. 1990 Jul-Aug;10(4):987-90. PubMed PMID: 2382998.

77: Maehara Y, Sakaguchi Y, Emi Y, Kusumoto T, Kohnoe S, Mori M, Sugimachi K. Primary and metastatic liver lesions of clinical colorectal cancer differ in chemosensitivity. Int J Colorectal Dis. 1990 May;5(2):87-9. PubMed PMID: 2358741.

78: Sekiguchi I, Suzuki M, Aida I, Tamada T, Nishida M. [Responsiveness of gynecological malignancies to oral antitumor agents in subrenal capsule assay and individualization of oral adjuvant chemotherapy]. Nippon Sanka Fujinka Gakkai Zasshi. 1990 May;42(5):437-42. Japanese. PubMed PMID: 2115558.

79: Kudoh S, Komiyama S, Miyazaki H, Matsui K. Appearance of drug-resistant tumor cells in a maxillary cancer patient undergoing chemotherapy and chemoradiotherapy. Am J Otolaryngol. 1990 May-Jun;11(3):165-9. PubMed PMID: 1696435.

80: Lin ST. [Study on chemosensitivity test (in vitro) of cultured human urogenital carcinoma cell lines by MTT assay]. Nippon Ika Daigaku Zasshi. 1990 Apr;57(2):127-36. Japanese. PubMed PMID: 1694861.

81: Nio Y, Imai S, Shiraishi T, Tsubono M, Morimoto H, Tseng CC, Tobe T. Chemosensitivity correlation between the primary tumors and simultaneous metastatic lymph nodes of patients evaluated by DNA synthesis inhibition assay. Cancer. 1990 Mar 15;65(6):1273-8. PubMed PMID: 2106383.

82: Ueda G, Abe Y, Yoshida M, Fujiwara T. Embryonal carcinoma of the ovary: a six-year survival. Int J Gynaecol Obstet. 1990 Mar;31(3):287-92. PubMed PMID: 1690671.

83: Nakao I, Ohashi Y, Ito K, Yokoyama T, Nishi I, Kanko T, Saito T. [Combination chemotherapy of non-small cell lung cancer (NSCLC) with cisplatin (CDDP), carboquone (CQ) and prednisolone (PDN)(PPQ therapy)]. Gan To Kagaku Ryoho. 1990 Feb;17(2):217-20. Japanese. PubMed PMID: 2154159.

84: Maehara Y, Emi Y, Sakaguchi Y, Kusumoto T, Kakeji Y, Kohnoe S, Sugimachi K. Estrogen-receptor-negative breast cancer tissue is chemosensitive in vitro compared with estrogen-receptor-positive tissue. Eur Surg Res. 1990;22(1):50-5. PubMed PMID: 2379525.

85: Maehara Y, Anai H, Sakaguchi Y, Kusumoto T, Emi Y, Sugimachi K. Detection of DNA strand breaks in HeLa cells in vitro and in mouse sarcoma 180 cells in vivo induced by an alkylating agent, carboquone, using in situ nick translation. Oncology. 1990;47(3):282-6. PubMed PMID: 2342771.

86: Kimura S, Uoshima N, Tanaka R, Kobayashi Y, Ozawa M, Maruo N, Kondo M, Abe T, Yoshida Y. [Polycythemia vera terminating in myelodysplastic syndrome]. Rinsho Ketsueki. 1990 Jan;31(1):100-4. Japanese. PubMed PMID: 2313900.

87: Watanabe Y, Shimizu J, Murakami S, Yoshida M, Tsubota M, Iwa T, Kitagawa M, Mizukami Y, Nonomura A, Matsubara F. Reappraisal of bronchial arterial infusion therapy for advanced lung cancer. Jpn J Surg. 1990 Jan;20(1):27-35. PubMed PMID: 2154638.

88: Mizuno K, Furuhashi Y, Maeda O, Iwata M, Misawa T, Kawai M, Kano T, Tomoda Y. Mitomycin C cross-resistance induced by adriamycin in human ovarian cancer cells in vitro. Cancer Chemother Pharmacol. 1990;26(5):333-9. PubMed PMID: 1976451.

89: Lusthof KJ, De Mol NJ, Janssen LH, Egberink RJ, Verboom W, Reinhoudt DN. Covalent binding studies on the 14C-labeled antitumor compound 2,5-bis(1-aziridinyl)-1,4-benzoquinone. Involvement of semiquinone radical in binding to DNA, and binding to proteins and bacterial macromolecules in situ. Chem Biol Interact. 1990;76(2):193-209. PubMed PMID: 1699678.

90: Maehara Y, Anai H, Kusumoto T, Sakaguchi Y, Emi Y, Kohnoe S, Sugimachi K. [Detection of cellular DNA strand breaks induced by antitumor drug and heat using in situ nick translation]. Nippon Geka Gakkai Zasshi. 1989 Sep;90(9):1576-8. Japanese. PubMed PMID: 2586469.

91: Yoh S, Arinaga M, Takagishi N, Isayama T, Soejima O, Fukabori Y, Yoshitake K, Izaki T. [Post-operative intra-arterial chemotherapy in patients with malignant bone and soft tissue tumors]. Gan To Kagaku Ryoho. 1989 Aug;16(8 Pt 2):2718-21. Japanese. PubMed PMID: 2782883.

92: Watanabe T, Morimoto S, Shinka T, Kawabata M, Satoh M, Yamada R. [Therapeutic embolization of renal angiomyolipoma: a case report]. Hinyokika Kiyo. 1989 Jul;35(7):1183-7. Japanese. PubMed PMID: 2801411.

93: Nio Y, Imai S, Shiraishi T, Ohgaki K, Tobe T. Lymphocytes anticancer chemosensitivity testing in vitro--an approach to predict immunosuppressive effect of anticancer agents. J Clin Lab Immunol. 1989 Jul;29(3):141-5. PubMed PMID: 2517429.

94: Nakao I. [Adverse reactions to carcinostatics and countermeasures]. Gan To Kagaku Ryoho. 1989 Apr;16(4 Pt 2-1):1099-107. Japanese. PubMed PMID: 2499262.

95: Akashi M, Sakamoto S, Ohta M, Kitagawa S, Yoshida M, Saito M, Takaku F, Miura Y. Treatment of multiple myeloma with carboquone-prednisolone. Eur J Haematol. 1989 Mar;42(3):265-9. PubMed PMID: 2924889.

96: Sekino Y, Suzuki Y, Sato N, Sadahiro M, Mohri H. [Open-heart surgery in a patient with chronic leukemia]. Nippon Geka Gakkai Zasshi. 1989 Mar;90(3):450-3. Japanese. PubMed PMID: 2770688.

97: Tsunoda S, Sasaki R, Miwa A, Sakurabayashi I, Miura Y. [Coma, hyperviscosity syndrome, hyperammonemia and myelofibrosis in a patient with IgG, lambda type multiple myeloma]. Rinsho Ketsueki. 1989 Mar;30(3):361-5. Japanese. PubMed PMID: 2504973.

98: Kobayashi K, Hino M, Kurane S, Yano T, Niitani H, Yamano Y, Hasegawa K, Tuboi E. [A comparative randomized phase II study of CDDP, CDDP-carboquone (CQ) and CDDP-etoposide as second-line chemotherapy in small cell lung cancer (SCLC)]. Gan To Kagaku Ryoho. 1989 Feb;16(2):207-12. Japanese. PubMed PMID: 2537605.

99: Maehara Y, Kusumoto H, Kusumoto T, Anai H, Sugimachi K. Tumor tissue is more sensitive to mitomycin C, carboquone, and aclacinomycin A than is adjacent normal tissue in vitro. J Surg Oncol. 1989 Jan;40(1):4-7. PubMed PMID: 2909804.

100: Sakata Y, Komatsu Y, Takagi S, Saitoh S, Itoh T, Suzuki H, Tsushima K, Sasaki D, Yoshida Y. Randomized controlled study of mitomycin C/carboquone/5-fluorouracil/OK-432 (MQ-F-OK) therapy and mitomycin C/5-fluorouracil/doxorubicin (FAM) therapy against advanced liver cancer. Cancer Chemother Pharmacol. 1989;23 Suppl:S9-12. PubMed PMID: 2647315.

101: Sampi K, Masaoka T, Takagi T, Sakamoto S, Mikuni C, Kano Y. [Aclarubicin-combined combination chemotherapy in patients with refractory or relapsed non-Hodgkin's lymphoma]. Gan To Kagaku Ryoho. 1989 Jan;16(1):79-82. Japanese. PubMed PMID: 2643395.

102: Kusumoto T, Maehara Y, Sakaguchi Y, Saku M, Sugimachi K. Hypoxia enhances the lethality of mitomycin C and carboquone against human malignant tumor cells in vitro. Eur Surg Res. 1989;21(3-4):224-31. PubMed PMID: 2509206.

103: Kusumoto H, Maehara Y, Kusumoto T, Anai H, Akazawa K, Sugimachi K. Chemosensitivity differences between primary and metastatic lesions of clinical gastric cancer. Eur J Surg Oncol. 1988 Dec;14(6):685-9. PubMed PMID: 3192005.

104: Akashi M, Ohta M, Kitagawa S, Furukawa Y, Takeda K, Muroi K, Komatsu N, Ikeda K, Ohsaka A, Yoshida M, et al. [Treatment of multiple myeloma: renal function in relation to its prognosis]. Rinsho Ketsueki. 1988 Nov;29(11):1991-7. Japanese. PubMed PMID: 3236408.

105: Sakata Y, Fukushi G, Tsushima K, Suzuki H, Kimura T, Kimura M, Tamura Y, Kishibe T, Saitoh S, Itoh T, et al. [MQF-FT and MQF-UFT in gallbladder and bile duct cancer]. Gan To Kagaku Ryoho. 1988 Sep;15(9):2731-5. Japanese. PubMed PMID: 3137889.

106: Kanematsu T, Maehara Y, Kusumoto T, Sugimachi K. Sensitivity to six antitumor drugs differs between primary and metastatic liver cancers. Eur J Cancer Clin Oncol. 1988 Sep;24(9):1511-3. PubMed PMID: 2846313.

107: Nasu K, Nakarai I, Horiuchi M, Shinoda A. [Clinical study of combination chemotherapy using carboquone, cisplatin, UFT and OK-432 in 7 cases of advanced gastric cancers and a relapsed gastric cancer]. Gan To Kagaku Ryoho. 1988 Aug;15(8 Pt 2):2410-3. Japanese. PubMed PMID: 3137878.

108: Sakata Y, Munakata A, Baba T, Saitoh S, Itoh T, Tamura Y, Furukohori N, Suzuki H, Kimura T, Kawata K, et al. [Controlled study of MQF-OK therapy with FT and with UFT on various advanced gastrointestinal cancers. Hirosaki Cooperative Study Group of Cancer Chemotherapy]. Gan To Kagaku Ryoho. 1988 Jul;15(7):2065-71. Japanese. PubMed PMID: 3134859.

109: Saito T. [An anticancer drug--carboquone]. Gan To Kagaku Ryoho. 1988 Mar;15(3):549-54. Review. Japanese. PubMed PMID: 3279914.

110: Maehara Y, Kusumoto H, Anai H, Kusumoto T, Sugimachi K. New cytoskeletal proteins are induced in HeLa cells by Vinca alkaloids. Oncology. 1988;45(3):187-91. PubMed PMID: 3130596.

111: Maehara Y, Anai H, Kusumoto H, Kusumoto T, Sugimachi K. Colorectal carcinoma in vitro is more sensitive to 1-hexylcarbamoyl-5-fluorouracil compared with six other antitumor drugs: carboquone, Adriamycin, mitomycin C, aclacinomycin A, cisplatin, 5-fluorouracil. Dis Colon Rectum. 1988 Jan;31(1):62-7. PubMed PMID: 3130239.

112: Koga T, Nakarai I, Rikitake H, Shinoda A. [A case of relapsed pulmonary carcinoma showing an interesting chemotherapeutic course]. Gan To Kagaku Ryoho. 1987 Dec;14(12):3355-8. Japanese. PubMed PMID: 3688895.

113: Uchibayashi T, Hisazumi H, Asari T, Kobashi K, Amano T, Naito K. [An in vitro chemosensitivity study using the human tumor clonogenic assay in urological malignancies: a preliminary report]. Hinyokika Kiyo. 1987 Oct;33(10):1575-80. Japanese. PubMed PMID: 3445845.

114: Kobayashi N. [Experimental and clinical study of a new embolic material in the treatment of malignant tumor--gelatin sponge containing carboquone]. Nippon Igaku Hoshasen Gakkai Zasshi. 1987 Sep 25;47(9):1127-44. Japanese. PubMed PMID: 3432057.

115: Ichihashi H, Kondo T, Nakazato H. [Clinical results of a randomized controlled trial on the effect of adjuvant immunochemotherapy using Esquinon and Krestin in patients with curatively resected gastric cancer--7-year survival--Cooperative Study Group for Cancer Immunochemotherapy, Tokai Gastrointestinal Oncology Group]. Gan To Kagaku Ryoho. 1987 Sep;14(9):2758-66. Japanese. PubMed PMID: 3307635.

116: Tari K, Satake I, Kojima S, Negishi T, Yoshida K, Nakame Y, Kanaoya F, Horiuchi S, Saito T, Owada F, et al. [Prophylactic intravesical chemotherapy in bladder tumors after surgery of upper tract urothelial carcinoma]. Hinyokika Kiyo. 1987 Jun;33(6):852-6. Japanese. PubMed PMID: 3118664.

117: Maehara Y, Anai H, Kusumoto H, Sugimachi K. Poorly differentiated human gastric carcinoma is more sensitive to antitumor drugs than is well differentiated carcinoma. Eur J Surg Oncol. 1987 Jun;13(3):203-6. PubMed PMID: 3036603.

118: Baba T, Taniguchi S. [Improvement of cancer therapy by angiotensin II-induced hypertension chemotherapy]. Gan To Kagaku Ryoho. 1987 Mar;14(3 Pt 2):971-7. Japanese. PubMed PMID: 3566298.

119: Hoshino S, Saito H, Wada M, Akutsu M, Shiozaki H, Takanashi M, Takei Y, Tanaka S, Teramura M, Takada K, et al. [Comparative studies of intermittent melphalan and prednisolone (MP) versus 5-drug regimen (QUVMP) and 3-drug regimen (QUP) in multiple myeloma]. Rinsho Ketsueki. 1987 Mar;28(3):358-65. Japanese. PubMed PMID: 3475485.

120: Nakajima K, Hisazumi H. Enhanced radioinduced cytotoxicity of cultured human bladder cancer cells using 43 degrees C hyperthermia or anticancer drugs. Urol Res. 1987;15(5):255-60. PubMed PMID: 3686753.

121: Maehara Y, Anai H, Kusumoto H, Sugimachi K. Carboquone alters the protein synthesis of Chinese hamster V79 cell. Oncology. 1987;44(4):253-6. PubMed PMID: 3614815.

122: Konami T. [Experimental study of chemotherapy of renal cell carcinoma. 1. Combination effect through the use of cell kinetics-directed treatment schedules]. Hinyokika Kiyo. 1987 Jan;33(1):1-14. Japanese. PubMed PMID: 3577958.

123: Saito T. [Influence of cell growth inhibitors on the eruption rate using the soft X-ray photographic method]. Shoni Shikagaku Zasshi. 1987;25(1):54-61. Japanese. PubMed PMID: 3506299.

124: Babaya K, Takahashi S, Momose H, Matsuki H, Sasaki K, Samma S, Ozono S, Hirao Y, Okajima E. Effects of single chemotherapeutic agents on development of urinary bladder tumor induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in rats. Urol Res. 1987;15(6):329-34. PubMed PMID: 3433593.

125: Shiraishi A, Katayama T, Matsuda T, Itoh Y, Haneishi T. Effects of a new antibiotic, isohematinic acid, on the resistance of mice to experimental infections. Microbiol Immunol. 1987;31(5):461-8. PubMed PMID: 3309579.

126: Yagita A, Orima I, Okada N, Ootsuka S, Oda T, Takeuchi N, Hosaka N, Matsumoto H, Itoh H, Ono M, et al. [A case report of patient with advanced stomach carcinoma of linitis plastica type responding to multi-immunotherapy and chemotherapy]. Gan To Kagaku Ryoho. 1987 Jan;14(1):196-9. Japanese. PubMed PMID: 3026254.

127: Naito K, Hisazumi H, Mihara S, Asari T, Kobashi K, Amano T, Uchibayashi T. Chemosensitivity study of urological malignancies using a novel dye-exclusion method. Cancer Chemother Pharmacol. 1987;20 Suppl:S1-5. PubMed PMID: 2822275.

128: Naito K, Hisazumi H, Asari T, Kobashi K, Amano T, Uchibayashi T. [An in vitro chemosensitivity study using human tumor clonogenic assay in urologic malignancies]. Hinyokika Kiyo. 1986 Dec;32(12):1959-66. Japanese. PubMed PMID: 3825833.

129: Kato T, Takamoto S, Ota K. [Antitumor effect of 1,3,3,5,5-pentaziridino-1-thia-2,4,6-triaza-3,5- diphoshorine-1-oxide]. Gan To Kagaku Ryoho. 1986 Dec;13(12):3401-7. Japanese. PubMed PMID: 3789752.

130: Nagamatsu Y, Nakarai I, Matsuo T, Kawahara M, Shinoda A. [A case of relapsed gastric cancer treated successfully by chemotherapy--lung metastasis and relapsed cancer in the hepatic portal system]. Gan To Kagaku Ryoho. 1986 Dec;13(12):3527-31. Japanese. PubMed PMID: 3098184.

131: Nakarai I, Ueno T, Hayashi A, Shinoda A. [Combination therapy of high-dose carboquone and OK-432 in unresectable non-small cell lung cancer]. Gan To Kagaku Ryoho. 1986 Dec;13(12):3508-12. Japanese. PubMed PMID: 3024582.

132: Osawa T. [Chemotherapy of renal cell carcinoma. II. Adriamycin and carboquone combined chemotherapy]. Nippon Hinyokika Gakkai Zasshi. 1986 Nov;77(11):1805-13. Japanese. PubMed PMID: 3573463.

133: Tanaka T, Yuasa M, Yamamoto A, Kawanishi Y, Numata A, Imagawa A. [Oral administration of 5-fluorouracil (5-FU) with intravesical chemotherapy as prophylaxis against recurrence of superficial bladder tumors]. Gan No Rinsho. 1986 Sep;32(11):1439-42. Japanese. PubMed PMID: 3773272.

134: Anai H, Maehara Y, Kusumoto H, Masuda H, Miyamoto K, Fukuchi K, Tamada R, Sugimachi K. [In vitro chemosensitivity of various human tumors evaluated by the succinate dehydrogenase inhibition (SDI) test (2)]. Gan To Kagaku Ryoho. 1986 Aug;13(8):2544-8. Japanese. PubMed PMID: 3740857.

135: Komiyama T, Kikuchi T, Sugiura Y. Interactions of anticancer quinone drugs, aclacinomycin A, adriamycin, carbazilquinone, and mitomycin C, with NADPH-cytochrome P-450 reductase, xanthine oxidase and oxygen. J Pharmacobiodyn. 1986 Aug;9(8):651-64. PubMed PMID: 3023600.

136: Koike K. [Experimental combination chemotherapy with carboquone and 5-fluorouracil of human germ cell tumors transplanted into nude mice]. Nippon Gan Chiryo Gakkai Shi. 1986 Jul 20;21(6):1302-10. Japanese. PubMed PMID: 3023505.

137: Maru A, Nantani M, Koyanagi T, Ohashi N, Yamada T, Fujieda J, Omuro H, Nishida T, Kusakai Y, Amino I, et al. [Prophylactic chemotherapy of transitional cell carcinoma of the bladder: the efficacy of long-term bladder instillation]. Nippon Hinyokika Gakkai Zasshi. 1986 Jul;77(7):1089-98. Japanese. PubMed PMID: 3784197.

138: Maehara Y, Anai H, Masuda H, Miyamoto K, Fukuchi K, Tamada R, Sugimachi K. [In vitro chemosensitivity testing evaluated by intracellular ATP level: ATP assay]. Gan To Kagaku Ryoho. 1986 Jul;13(7):2342-5. Japanese. PubMed PMID: 3729490.

139: Nio Y, Ohgaki K, Inamoto T, Kan N, Kodama H, Tobe T. [An in vitro sensitivity assay for anti-cancer agents by measuring the inhibition rate of DNA synthesis (3H-thymidine uptake of cancer cells). II. Clinical study of 110 cases of breast cancer]. Nippon Geka Gakkai Zasshi. 1986 Jun;87(6):680-96. Japanese. PubMed PMID: 3016495.

140: Ichihashi H, Akiyama S, Takagi H. Correlation of an in vitro chemosensitivity test using [3H] incorporation with the response in case of human tumor chemotherapy. Jpn J Surg. 1986 May;16(3):195-201. PubMed PMID: 3090333.

141: Niikura H. [Thrombosis in various diseases: myeloproliferative disorders]. Nippon Rinsho. 1986 May;44(5):1144-52. Review. Japanese. PubMed PMID: 2943916.

142: Ichihashi H. [Clinical application of chemosensitivity testing using radioactive precursors]. Gan To Kagaku Ryoho. 1986 Apr;13(4 Pt 2):1156-62. Japanese. PubMed PMID: 3729437.

143: Kusai A, Ueda S. The stability of carboquone in alcohols. II. Kinetics and mechanisms of degradation of carboquone in methanol. Chem Pharm Bull (Tokyo). 1986 Mar;34(3):1299-308. PubMed PMID: 3731347.

144: Takahagi H, Inoue K, Horiguchi M. Drug monitoring by a fully automated high-performance liquid chromatographic technique, involving direct injection of plasma. J Chromatogr. 1986 Feb 21;352:369-79. PubMed PMID: 3457796.

145: Nakazato H, Ichihashi H, Kondo T. [Clinical results of a randomized controlled trial on the effect of adjuvant immunochemotherapy using Esquinon and Krestin in patients with curatively resected gastric cancer. Cooperative Study Group of Cancer Immunochemotherapy, Tokai Gastrointestinal Oncology Group]. Gan To Kagaku Ryoho. 1986 Feb;13(2):308-18. Japanese. PubMed PMID: 3947108.

146: Sugawa T, Yamagata S. [Differing progress patterns in cancer of the uterine cervix and variant effects of adjuvant chemotherapy based on histological type]. Gan To Kagaku Ryoho. 1986 Feb;13(2):210-5. Japanese. PubMed PMID: 3080962.

147: Nakagami Y, Kishimoto T, Matsumoto K. [Experimental study on immunochemotherapy (PSK, CQ) in rat bladder cancer (BC-47)]. Gan To Kagaku Ryoho. 1985 Oct;12(10):1968-74. Japanese. PubMed PMID: 4051512.

148: Shinkai T, Saijo N, Yoshioka S, Suemasu K, Hasegawa H, Miyazawa N, Kamiya T, Kanzawa F, Nakajima T, Shimosato Y. Recurrence of thymoma with appearance of myasthenia gravis 18 years after surgery: a case report. Jpn J Clin Oncol. 1985 Sep;15(3):567-75. PubMed PMID: 4057633.

149: Kawano S, Kubota M, Tanaka K, Ogawa H. [Experience of intra-arterial chemotherapy for advanced bladder cancer with antitumor agents]. Nippon Hinyokika Gakkai Zasshi. 1985 Sep;76(9):1393-400. Japanese. PubMed PMID: 3936961.

150: Okada J, Kusai A, Ueda S. Core treatment for improving microencapsulability in simple gelatin coacervation method. J Microencapsul. 1985 Jul-Sep;2(3):175-82. PubMed PMID: 3880484.

151: Carmichael AJ, Samuni A, Riesz P. Photogeneration of superoxide and decarboxylated peptide radicals by carboquone, mitomycin C and streptonigrin. An electron spin resonance and spin trapping study. Photochem Photobiol. 1985 Jun;41(6):635-42. PubMed PMID: 2991956.

152: Fujiya S, Yasuda M, Tahira K, Nakabayashi Y, Yoshioka M, Terashima Y, Hatiya S. [In vitro sensitivity test of a cultured human ovarian cancer cell line to anticancer agents]. Gan To Kagaku Ryoho. 1985 May;12(5):1080-7. Japanese. PubMed PMID: 3922310.

153: Komiyama T, Sawada MT, Kobayashi K, Yoshimoto A. Enhanced production of ethylene from methional by iron chelates and heme containing proteins in the system consisting of quinone compounds and NADPH-cytochrome P-450 reductase. Biochem Pharmacol. 1985 Apr 1;34(7):977-83. PubMed PMID: 3921033.

154: Ishikawa S, Hayashi K, Ree T, Saotome K, Yanai N, Iriki A, Kimura S, Hirata M, Nishiyama Y, Kawamura M, et al. [Long-term results of the pulmonary resection with and without combined antineoplastic agents for primary bronchogenic carcinoma]. Kyobu Geka. 1985 Feb;38(2):113-7. Japanese. PubMed PMID: 3921745.

155: Mickey DD. Combined therapeutic effects of an immunomodulator, PSK, and chemotherapy with carboquone on rat bladder carcinoma. Cancer Chemother Pharmacol. 1985;15(1):54-8. PubMed PMID: 4006049.

156: Nio Y, Inamoto T, Ohgaki K, Kan N, Hori T, Nakayama N, Yamasaki N, Hikasa Y. [An in vitro sensitivity assay of anti-cancer agents by measuring the inhibition rate of DNA synthesis (3H-thymidine uptake) of cancer cells--clinical study]. Nippon Geka Gakkai Zasshi. 1985 Jan;86(1):8-22. Japanese. PubMed PMID: 3974569.

157: Watanabe Y, Sato H, Iida S, Yamada T, Kobayashi H, Kimoto H, Tsunamura Y, Ichihashi T, Shimizu J, Hashizume Y, et al. [Clinical value of postoperative chemotherapy for non-small cell lung cancer--with special reference to long-term combined chemotherapy combined with immunotherapy]. Gan To Kagaku Ryoho. 1985 Jan;12(1):21-35. Japanese. PubMed PMID: 2981515.

158: Okazaki A, Niibe H, Mitsuhashi N, Ito J, Tatezawa T, Sakaino K, Baba T, Sakata N. [Effects of PS-K as adjuvant therapy for primary lung cancer--an autopsy case]. Gan No Rinsho. 1984 Oct;30(13):1707-12. Japanese. PubMed PMID: 6513025.

159: Fukuma H, Beppu Y, Nishikawa K. [Adjuvant chemotherapy in the treatment of primary soft tissue sarcomas, with special reference to intra-arterial infusion chemotherapy]. Gan To Kagaku Ryoho. 1984 Sep;11(9):1729-35. Japanese. PubMed PMID: 6476841.

160: Mizuno H, Inomata T, Umezawa T, Shimizu F, Arakawa M. [Antitumor effect of FU-O-G, new antitumor agent, following long term administration]. Gan To Kagaku Ryoho. 1984 Sep;11(9):1848-54. Japanese. PubMed PMID: 6433807.

161: Nishi Y, Hasegawa MM, Taketomi M, Ohkawa Y, Inui N. Comparison of 6-thioguanine-resistant mutation and sister chromatid exchanges in Chinese hamster V79 cells with forty chemical and physical agents. Cancer Res. 1984 Aug;44(8):3270-9. PubMed PMID: 6744262.

162: Ohmori H. [Intravesical chemotherapy for superficial bladder tumors]. Gan To Kagaku Ryoho. 1984 Aug;11(8):1557-62. Japanese. PubMed PMID: 6206797.

163: Fukuoka M, Takada M, Tamai S, Negoro S, Matsui K, Ryu S, Sakai N, Sakaguchi K. [Local application of anti-cancer drugs for the treatment of malignant pleural and pericardial effusion]. Gan To Kagaku Ryoho. 1984 Aug;11(8):1543-9. Japanese. PubMed PMID: 6206796.

164: Ninomiya K, Sekido S, Araki T. [Effect of combination chemotherapy of nitrosourea MCNU with various anti-tumor agents]. Gan To Kagaku Ryoho. 1984 Jun;11(6):1315-23. Japanese. PubMed PMID: 6428326.

165: Kakizoe T, Matsumoto K, Nishio Y, Ohtani M, Miyazawa N. Chemotherapy by bronchial arterial infusion for pulmonary metastases of renal cell carcinoma. J Urol. 1984 Jun;131(6):1053-5. PubMed PMID: 6427476.

166: Shinkai T, Saijo N, Tominaga K, Eguchi K, Shimizu E, Takahashi K, Sasaki Y, Ohkura H. [The value of carcinoembryonic antigens in patients with advanced lung cancer: in relation to chemotherapy]. Gan To Kagaku Ryoho. 1984 May;11(5):1056-63. Japanese. PubMed PMID: 6202246.

167: Yoshikawa H, Sao H, Tahara T, Akao Y, Yoshikawa S. [A case of refractory acute lymphocytic leukemia who achieved a complete remission by mitoxantrone]. Gan To Kagaku Ryoho. 1984 Mar;11(3):515-20. Japanese. PubMed PMID: 6584088.

168: Wakui A, Sato H. [Clinical studies on induced hypertension chemotherapy based on functional characteristics of microcirculation of tumor vessels]. Gan To Kagaku Ryoho. 1984 Mar;11(3 Pt 2):741-9. Japanese. PubMed PMID: 6424580.

169: Ohkawa K, Tsukada Y, Hirai H. [Effect of antibody to rat alpha-fetoprotein (AFP) on protein and DNA synthesis of rat ascites hepatoma AH66 cells]. Gan To Kagaku Ryoho. 1984 Feb;11(2):227-34. Japanese. PubMed PMID: 6198967.

170: Maeyama M, Tayama C, Inoue S, Tajima C, Onizuka Y, Tanaka N, Nakayama M, Iwamasa T. Serial serum determination on alpha-fetoprotein as a marker of the effect of postoperative chemotherapy in ovarian endodermal sinus tumor. Gynecol Oncol. 1984 Jan;17(1):104-16. PubMed PMID: 6198243.

171: Himori T, Wakui A, Saito T. Clinical evaluation of anticancer alkylating agent, carboquone (NSG-134679). Sci Rep Res Inst Tohoku Univ Med. 1983 Dec;30(1-4):92-9. PubMed PMID: 6678502.

172: Uchibayashi T, Hisazumi H, Saitoh Y, Naitoh K, Misaki T, Nango C, Tajiri S, Nakamura T, Kojima A, Mikawa I. [Combination chemotherapy with adriamycin, carboquone and 5-Fu for bladder cancer]. Hinyokika Kiyo. 1983 Dec;29(12):1617-23. Japanese. PubMed PMID: 6677109.

173: Nakata H. [Experimental combination chemotherapy with vincristine and carboquone in human ovarian cancer transplanted into nude mice]. Nippon Sanka Fujinka Gakkai Zasshi. 1983 Nov;35(11):1991-8. Japanese. PubMed PMID: 6663131.

174: Yamanaka H, Kaburagi Y, Imai K, Miki M. [Experimental and clinical studies on intravesical instillation therapy for bladder cancer]. Hinyokika Kiyo. 1983 Nov;29(11):1427-32. Japanese. PubMed PMID: 6428193.

175: Takai K, Moriyama N, Shinohara M, Fukutani K, Mikata N, Yokoyama M, Kogure T. [Synchronous double cancer of the esophagus and the urinary bladder: report of two cases]. Hinyokika Kiyo. 1983 Sep;29(9):1085-9. Japanese. PubMed PMID: 6677142.

176: Okajima E, Ijuin M, Hiramatsu T, Kihoin K, Hirao Y, Ohara S, Hijioka T, Babaya K, Shiomi T, Samma S, et al. [Fundamental studies on intravesical instillation of carboquone for treatment of urinary bladder tumors--on the effects of intravesical instillation of carboquone in normal beagle dogs]. Hinyokika Kiyo. 1983 Sep;29(9):1061-74. Japanese. PubMed PMID: 6428197.

177: Uchibayashi T. [Chemosensitivity in established human bladder carcinoma and HELA cell lines in vitro]. Nippon Hinyokika Gakkai Zasshi. 1983 Sep;74(9):1606-20. Japanese. PubMed PMID: 6202921.

178: Yoh S, Takagishi N, Iwasaki H, Eimoto T, Ono Y, Okasaki M. [Intraarterial high-dose adriamycin for patients with skeletal or soft tissue sarcoma]. Gan No Rinsho. 1983 Aug;29(10):1263-73. Japanese. PubMed PMID: 6632206.

179: Wakui A, Suzuki M. [Cancer chemotherapy in combination with angiotensin-induced hypertension]. Gan To Kagaku Ryoho. 1983 Jul;10(7):1577-83. Japanese. PubMed PMID: 6409008.

180: Shinkai T, Saijo N, Tominaga K, Eguchi K, Shimizu E, Shibuya M, Shimabukuro Z, Koketsu H, Nakajima T, Niitani H. Pulmonary toxicity induced by pepleomycin 3-[(S)-1'-phenylethylamino] propylamino-bleomycin. Jpn J Clin Oncol. 1983 Jun;13(2):395-410. PubMed PMID: 6193296.

181: Kojima J, Kamada T, Monna J. [Clinical study on combination chemotherapy of primary liver cancer]. Gan To Kagaku Ryoho. 1983 Apr;10(4 Pt 1):997-1006. Japanese. PubMed PMID: 6408995.

182: Saijo N, Shimizu E, Eguchi K, Shinkai T, Tominaga K, Shibuya M, Shimabukuro Z, Niitani H, Hoshi A. Effect of peplomycin plus carbazilquinone and mitomycin on non-small cell carcinoma of the lung. Cancer Treat Rep. 1983 Apr;67(4):385-7. PubMed PMID: 6189601.

183: Ueda Y, Saito A, Fukuoka Y, Yamashiro Y, Ikeda Y, Taki H, Yasuda T, Saikawa I. Interactions of beta-lactam antibiotics and antineoplastic agents. Antimicrob Agents Chemother. 1983 Mar;23(3):374-8. PubMed PMID: 6405686; PubMed Central PMCID: PMC184655.

184: Yoshida O, Miyakawa M, Watanabe H, Mishina T, Kobayashi T, Nakagawa K, Fukuyama T, Ogura K, Ueyama H, Itoh H, et al. [Study of combination chemotherapy with cytosine arabinoside in the intravesical treatment of superficial bladder tumors]. Hinyokika Kiyo. 1983 Mar;29(3):357-64. Japanese. PubMed PMID: 6233856.

185: Moriyama M, Kubota Y, Miura T, Shuin T, Noguchi S. [The effect of intravesical chemotherapy on superficial urinary bladder cancer]. Hinyokika Kiyo. 1983 Mar;29(3):351-5. Japanese. PubMed PMID: 6203382.

186: Hisazumi H, Nakajima K, Uchibayashi T. Chemosensitivity of established human bladder carcinoma cell lines in vitro. Gann. 1983 Feb;74(1):176-82. PubMed PMID: 6840436.

187: Nakagami Y, Minowa T, Tozuka K, Hiraoka Y, Chin H. Evaluation of multidisciplinary treatment of bladder cancer, especially in chemoimmunotherapy (ADM and OK-432) as a consolidation therapy. Cancer Chemother Pharmacol. 1983;11 Suppl:S47-50. PubMed PMID: 6605813.

188: Himori T, Ujiie S, Mimata Y, Sugiyama Z, Wakui A. Total tumor cell count and hematopoietic system of ah 109A-bearing rats treated with mitomycin C and carboquone. Sci Rep Res Inst Tohoku Univ Med. 1982 Dec;29(1-4):77-86. PubMed PMID: 6308758.

189: Monna T, Kanno T, Marumo T, Harihara S, Kuroki T, Yamamoto S, Kobayashi N, Sato M, Nakamura K, Nakatsuka H, Onoyama Y, Yamada R. A comparison of transcatheter arterial embolization with one shot therapy for the patients with hepatic cell carcinoma. Gastroenterol Jpn. 1982 Dec;17(6):542-9. PubMed PMID: 6298047.

190: Komiyama T, Kikuchi T, Sugiura Y. Generation of hydroxyl radical by anticancer quinone drugs, carbazilquinone, mitomycin C, aclacinomycin A and adriamycin, in the presence of NADPH-cytochrome P-450 reductase. Biochem Pharmacol. 1982 Nov 15;31(22):3651-6. PubMed PMID: 6295407.

191: Tsukada K, Okada R, Hisaoka M, Morioka T. Liposome-encapsulated carboquone. I. Method of preparation and carboquone release. Chem Pharm Bull (Tokyo). 1982 Oct;30(10):3679-84. PubMed PMID: 7160014.

192: Uzuka Y, Saito Y, Takahashi H, Komatsu M. Carboquone therapy for hematologic neoplasms. Tohoku J Exp Med. 1982 Oct;138(2):151-60. PubMed PMID: 6960553.

193: Saijo N, Shimizu E, Shibuya M, Irimajiri N, Takizawa T, Eguchi K, Shinkai T, Tominaga K, Shimabukuro Z, Taniguchi T, Hoshi A. Effect of chemotherapy on natural-killer activity and antibody-dependent cell-mediated cytotoxicity in carcinoma of the lung. Br J Cancer. 1982 Aug;46(2):180-9. PubMed PMID: 6185128; PubMed Central PMCID: PMC2011091.

194: Nakarai I, Honda T, Jinnai S, Kita T, Shinoda A. [Combination therapy of large amount of carboquone and OK-432 for unresectable lung cancer]. Gan To Kagaku Ryoho. 1982 Jul;9(6):1006-11. Japanese. PubMed PMID: 7184436.

195: Inoue S, Fukuda O, Tajima C, Tokunaga T, Nakayama M, Maeyama M. [Combined administration of futraful and esquinone for the treatment of advanced ovarian cancer]. Gan To Kagaku Ryoho. 1982 Jul;9(7):1226-30. Japanese. PubMed PMID: 6820911.

196: Saijo N. [Chemotherapy against pulmonary metastasis from uterine cervical carcinoma]. Gan To Kagaku Ryoho. 1982 Jul;9(6):992-7. Japanese. PubMed PMID: 6191708.

197: Masuda H, Sumiyoshi Y, Shiojima Y, Kikyo T, Fujiyama N, Iwata M, Machida Y, Nagai K. Local therapy of carcinoma of the uterine body (1st report). Asia Oceania J Obstet Gynaecol. 1982 Jun;8(2):117-26. PubMed PMID: 6182870.

198: Okajima E, Hiramatsu T, Okamoto M, Kihoin K, Ijuin M, Hirao Y, Ohara S, Babaya K, Kubota K, Samma S, Okamura K, Kaneko Y, Horii Y, Moriya A. [Effect of carboquone (esquinone) on the development of urinary bladder tumors in rats induced by N-butyl-N-(4-hydroxybutyl) nitrosamine]. Gan To Kagaku Ryoho. 1982 May;9(5):836-42. Japanese. PubMed PMID: 7184430.

199: Katoh T, Ishige H, Takamizawa H, Tokita H, Tanaka N. [Effects of various agents on human choriocarcinoma transplanted to nude mice]. Gan To Kagaku Ryoho. 1982 May;9(5):843-8. Japanese. PubMed PMID: 6892200.

200: Sekiya S, Iwasawa H, Takamizawa H. [Maintenance chemotherapy for ovarian adenocarcinoma with carboquone: doses and side effects (author's transl)]. Nippon Sanka Fujinka Gakkai Zasshi. 1982 May;34(5):634-6. Japanese. PubMed PMID: 6282997.

201: Hisaoka M, Morioka T, Yagita A. Determination of carboquone in plasma and ascites by high performance liquid chromatography after intravenous and intraperitoneal administration in man. Gann. 1982 Apr;73(2):161-6. PubMed PMID: 7117751.

202: Yokoyama K, Kaito S, Sobajima T, Fukumoto H, Horiguchi Y, Takeuchi A, Kurokawa A. [Effects of pepleomycin (PEP) infused through bronchial artery for lung cancer: in comparison with the cases of mitomycin (MMC) or carboquon (CQ)]. Gan To Kagaku Ryoho. 1982 Apr;9(4):688-93. Japanese. PubMed PMID: 6191702.

203: Shinkai K, Arakawa M. [Effect of carboquone in complete regression of mouse mammary cancer MM-46]. Gan To Kagaku Ryoho. 1982 Mar;9(3):556-7. Japanese. PubMed PMID: 7184412.

204: Matsumura Y. [Intravesical instillation of adriamycin and other antineoplastic agents]. Gan To Kagaku Ryoho. 1982 Mar;9(3):372-6. Japanese. PubMed PMID: 7184406.

205: Motoyama T. [Quantitative analysis on in vitro drug sensitivity of cultured human ovarian cancer cell lines (author's transl)]. Nippon Sanka Fujinka Gakkai Zasshi. 1982 Mar;34(3):308-14. Japanese. PubMed PMID: 7069245.

206: Negoro S, Fukuoka M, Takada M, Tamai S, Sakai N, Matsui K. [Combination chemotherapy with peplomycin and carboquone (esquinon) for squamous cell carcinoma of the lung]. Gan To Kagaku Ryoho. 1982 Mar;9(3):522-8. Japanese. PubMed PMID: 6191699.

207: Yajima A, Mori T, Wakisaka T, Sato S, Sakahira H, Yamauchi R, Suzuki M. FQC combination chemotherapy for primary malignant ovarian tumor. Gynecol Oncol. 1982 Feb;13(1):93-100. PubMed PMID: 6800893.

208: Hoshiya T, Matsunaga T, Hyo Y, Mori N, Kakiuchi H, Saeki K, Wakuda K. [Compound therapy including PSK for malignant head and neck cancer]. Gan To Kagaku Ryoho. 1982 Jan;9(1):91-5. Japanese. PubMed PMID: 7184365.

209: Tsuya A, Kaneda K, Mikuriya S, Horiuchi J, Amino S, Mochizuki S, Kamata R, Ikeda M, Okawa T. [Evaluation of a combined application of radiotherapy, carboquone, and PSK in malignant tumor--clinical results at 7 facilities]. Gan No Rinsho. 1982;28(1):49-54. Japanese. PubMed PMID: 7182548.

210: Hisaoka M, Tsukada K, Morioka T, Inomata T, Arakawa M. Studies on liposome-encapsulated carboquone. IV. Enhancement of antitumor activity of carboquone against Ehrlich ascites carcinoma by encapsulation. J Pharmacobiodyn. 1982 Jan;5(1):34-9. PubMed PMID: 7077520.

211: Hisaoka M, Tsukada K, Morioka T. Studies on liposome-encapsulated carboquone. III. Enhancement of lymphatic transport of carboquone by encapsulation. J Pharmacobiodyn. 1982 Jan;5(1):27-33. PubMed PMID: 7077519.

212: Hisaoka M, Tsukada K, Morioka T. Studies on liposome-encapsulated carboquone II. Effect of liposomal encapsulation of carboquone on distribution and clearance in animals. J Pharmacobiodyn. 1982 Jan;5(1):18-26. PubMed PMID: 7077518.

213: Sakata Y, Yoshida Y, Komatsu Y, Sugawara K, Nishimura S, Kikuchi K. [MQF-OK therapy in advanced terminal stomach cancer--with special reference to a comparison with MFC therapy]. Gan To Kagaku Ryoho. 1982 Jan;9(1):109-15. Japanese. PubMed PMID: 6820875.

214: Sugimori H, Kidera Y, Matsuyama T. [Combined chemotherapy of ovarian cancer with special reference to carboquone]. Gan To Kagaku Ryoho. 1982 Jan;9(1):66-71. Japanese. PubMed PMID: 6307172.

215: Niikura H, Hagiwara S, Nishiyama H, Mori H, Mohri H, Matsuno K, Terada H. [Therapy of polycythemia vera and essential thrombocythemia with carboquone (author's transl)]. Rinsho Ketsueki. 1981 Nov;22(11):1700-7. Japanese. PubMed PMID: 7339013.

216: Masuda H, Sumiyoshi Y, Shiojima Y, Suda T, Kikyo T, Iwata M, Fujiyama N, Machida Y, Nagai K. Local therapy of carcinoma of the uterine cervix: part I. Cancer. 1981 Oct 15;48(8):1899-906. PubMed PMID: 6169425.

217: Goto M, Mitsuoka A, Sugiyama M, Kitano M. Enhancement of delayed hypersensitivity reaction with varieties of anti-cancer drugs. A common biological phenomenon. J Exp Med. 1981 Jul 1;154(1):204-9. PubMed PMID: 6788892; PubMed Central PMCID: PMC2186397.

218: Kikuchi T, Sugiura Y, Komiyama T. Generation of semiquinone radical from carbazilquinone by NADPH-cytochrome P-450 reductase. Biochem Pharmacol. 1981 Jun 15;30(12):1717-8. PubMed PMID: 6268108.

219: Taniguchi S, Kimura NT, Baba T. Effects of pH on cytotoxicity of carboquone. Jpn J Pharmacol. 1981 Apr;31(2):243-7. PubMed PMID: 7311142.

220: Kondo T, Sakamoto J, Ichihashi H, Kamei H. Effect of alternating administration of PS-K and carbazilquinone in tumor-bearing mice. Gann. 1981 Apr;72(2):293-9. PubMed PMID: 7286551.

221: Itami M, Yamada R, Nakatsuka H, Nakamura K, Sato M, Kobayashi N, Takashima S, Minakuchi K, Yamashita A, Onoyama Y. [New embolic material for therapeutic embolization of malignant tumor--gelatin sponge containing carbazilquinone (author's transl)]. Nippon Igaku Hoshasen Gakkai Zasshi. 1981 Jan 25;41(1):75-8. Japanese. PubMed PMID: 7232114.

222: Hisazumi H, Uchibayashi T, Katoh M, Kobayashi T, Nakajima K, Naitoh K, Misaki T, Kuroda K. Anticancer drug sensitivity in vitro in the bladder cancer cell line, KK-47 and prophylactic use of carbazilquinone and urokinase in bladder cancer. Urol Res. 1981;9(5):231-5. PubMed PMID: 7029855.

223: Arai T, Takahashi K, Ishiguro K, Mikami Y. Some chemotherapeutic properties of two new antitumor antibiotics, saframycins A and C. Gann. 1980 Dec;71(6):790-6. PubMed PMID: 7274625.

224: Sawada M, Hayakawa K, Matsui Y, Nishiura H, Okudaira Y. [Chemotherapy of yolk sac tumor heterotransplanted to nude mice (author's transl)]. Nippon Sanka Fujinka Gakkai Zasshi. 1980 Oct;32(10):1596-602. Japanese. PubMed PMID: 7240825.

225: Yajima A, Higashiiwai H, Sato A, Watanabe M, Mori T, Suzuki M, Hanyu T, Suzuki K, Kinii H, Moritsuka T, Igarashi N, Nakano M, Nagasawa K, Sato S. Combination chemotherapy in advanced ovarian cancer. Tohoku J Exp Med. 1980 Oct;132(2):225-9. PubMed PMID: 6777904.

226: Mizuno S, Amagai M, Ishida A. Synergistic cell killing by antitumor agents and hyperthermia in cultured cells. Gann. 1980 Aug;71(4):471-8. PubMed PMID: 6159245.

227: Uehara N, Shirakawa S, Uchino H, Saeki Y, Nozaki M. Elevated polyamine levels in erythrocytes of SLC:ICR mice inoculated with Ehrlich ascites carcinoma cells. Life Sci. 1980 Feb 11;26(6):461-7. PubMed PMID: 7374356.

228: Machida Y, Masuda H, Fujiyama N, Iwata M, Nagai T. Preparation and phase II clinical examination of topical dosage forms for the treatment of carcinoma colli containing bleomycin, carboquone, or 5-fluorouracil with hydroxypropyl cellulose. Chem Pharm Bull (Tokyo). 1980;28(4):1125-30. PubMed PMID: 6158378.

229: Miyamoto T. Recent results of using a sequential combination of bleomycin and mitomycin C in the treatment of metastatic cervical cancer. Recent Results Cancer Res. 1980;70:211-7. PubMed PMID: 6153471.

230: Kamura T, Aoki K, Nishikawa K, Baba T. Antitumor effect of thermodifferential chemotherapy with carboquone on Ehrlich carcinoma. Gann. 1979 Dec;70(6):783-90. PubMed PMID: 535687.

231: Hashimoto R, Yamazaki Y, Shiozaki K, Akai S, Shimada K, Sato M, Kurita Y, Hirono T, Sato Y. [An operated case of the lung cancer associated with the esophageal necrosis due to the bronchial artery infusion (author's transl)]. Kyobu Geka. 1979 Nov;32(11):862-5. Japanese. PubMed PMID: 513385.

232: Sakata Y, Sugawara K, Komatsu Y, Yoshida Y, Nishimura S, Kikuchi K. [Combination chemotherapy of mitomycin-C, carboquone, 5-fluorouracil and OK-432 for inoperable gastric cancer (author's transl)]. Nippon Gan Chiryo Gakkai Shi. 1979 Oct 20;14(6):978-87. Japanese. PubMed PMID: 541534.

233: Kato T, Nemoto R, Nishimoto T, Kumagai I, Miura K. Chemosensitivity of human bladder cancer cells in long-term culture and clinical responses to the selected anticancer drug. Cancer. 1979 Jul;44(1):58-63. PubMed PMID: 455264.

234: Misawa S, Sawai K, Takino T, Masuda M, Abe T, Kawai K. Clinical studies on the combined immunochemotherapy with a streptococcal preparation (Picibanil) and other anticancer drugs. Nippon Gan Chiryo Gakkai Shi. 1979 Jun 20;14(3):291-305. PubMed PMID: 479655.

235: Baba T, Aoki K, Kimura NT, Kamura T, Nishikawa K, Taniguchi S. Potentiation of anticancer effect of carboquone in vivo by glucose pretreatment. Gann. 1979 Apr;70(2):255-8. PubMed PMID: 467889.

236: Tsukeda H, Mizuno S, Nitta K. Susceptibilities of normal and malignant human lung cells in culture to the cytocidal action of antitumor agents. Cancer Res. 1978 Aug;38(8):2529-32. PubMed PMID: 149590.

237: Seino Y, Nagao M, Yahagi T, Hoshi A, Kawachi T, Sugimura T. Mutagenicity of several classes of antitumor agents to Salmonella typhimurium TA98, TA100, and TA92. Cancer Res. 1978 Jul;38(7):2148-56. PubMed PMID: 350383.

238: Kanamaru R, Asamura M, Hayashi Y, Sato H, Saito T. Damage of DNA and its recovery in AH-109A cells treated with carboquone in vivo. Tohoku J Exp Med. 1978 Apr;124(4):331-7. PubMed PMID: 663931.

239: Kidera Y, Baba T. Blood flow-interrupting hyperthermic chemotherapy on established autochthonous mouse sarcoma induced by 3-methylcholanthrene. Cancer Res. 1978 Mar;38(3):556-9. PubMed PMID: 626960.

240: Sakurai Y. Synthetic analogs of antitumor drugs under development in Japan. Recent Results Cancer Res. 1978;63:272-81. PubMed PMID: 705011.

241: Ogawa M. A recent overview of chemotherapy for advanced stomach cancer in Japan. Antibiot Chemother. 1978;24:149-59. Review. PubMed PMID: 350134.

242: Wakabayashi Y, Takaku F. [Studies of carboquone therapy on chronic myelogenous leukemia (author's transl)]. Rinsho Ketsueki. 1978 Jan;19(1):9-14. Japanese. PubMed PMID: 273114.

243: Mori T, Kayama T, Katakura R. [Medulloblastoma with intractable ascites treated by carboquone--a complication of a ventriculoperitoneal shunt (author's transl)]. No Shinkei Geka. 1977 Nov;5(12):1299-303. Japanese. PubMed PMID: 593523.

244: Fujimoto S, Inagaki J, Horikoshi N, Hoshino A. Combination chemotherapy of 6-thioguanine with various antitumor agents against murine leukemia L-1210. Gann. 1977 Oct;68(5):543-52. PubMed PMID: 201534.

245: Sato S, Iwaizumi M, Handa K, Tamura Y. Electron spin resonance study on the mode of generation of free radicals of daunomycin, adriamycin, and carboquone in NAD(P)H-microsome system. Gann. 1977 Oct;68(5):603-8. PubMed PMID: 22473.

246: Iigo M, Kanzawa F, Nakamura A, Hoshi A, Kuretani K. Interaction of antitumor agents including doxorubicin or daunorubicin in sarcoma-180 system. Gann. 1977 Aug;68(4):459-64. PubMed PMID: 616416.

247: Mori T, Fukawa O, Sato T, Hori S. [Regression of a recurrent malignant glioma by combined chemoradiotherapy utilizing carboquone, FT-207 and telecobalt--report of a case (author's transl)]. No Shinkei Geka. 1977 Jul;5(8):865-9. Japanese. PubMed PMID: 331131.

248: Tamura Y, Sato S. Stimulation of a reconstituted, microsomal NADH oxidase system by carboquone, a quinoid anticancer chemical. Gann. 1977 Jun;68(3):353-6. PubMed PMID: 199521.

249: Saito S, Takahashi Y, Ooshima H, Matuda G. [Chemotherapy of bladder neoplasms--instillation of carboquone into the bladder]. Nippon Rinsho. 1977 May;35(5):1983-7. Japanese. PubMed PMID: 560545.

250: Baba T, Kimura NT, Kanematsu T, Aoki K, Kidera Y. Experiments on thermodifferential chemotherapy with thoracotomy for blood-borne pulmonary metastasis in rats. Gann. 1977 Apr;68(2):165-74. PubMed PMID: 892291.

251: Okada N, Arakawa M. Comparative studies on the antitumor effect on intravenous administration of carbazilquinone and mitomycin-C. Gann. 1976 Dec;67(6):805-12. PubMed PMID: 1021507.

252: Iigo M, Nakamura A, Hoshi A, Kuretani K. Interaction of antitumor agents including carboquone in sarcoma-180 system. Gann. 1976 Oct;67(5):641-4. PubMed PMID: 1017581.

253: Kidera Y, Kamura T, Aoki K, Kimura M, Baba T. [Protective effects of general hypothermia on side effects of anticancer drugs in the "regional hyperthermic chemotherapy combined with temporary interruption of local blood-circulation" (author's transl)]. Fukuoka Igaku Zasshi. 1976 Sep;67(9):325-30. Japanese. PubMed PMID: 1033893.

254: Handa K, Sato S. Stimulation of microsomal NADPH oxidation by quinone group-containing anticancer chemicals. Gann. 1976 Aug;67(4):523-8. PubMed PMID: 15920.

255: Baba T, Aoki K, Kidera Y, Kimura M, Kanematsu T. Temporary interruption of regional blood flow combined with local hyperthermia for cancer chemotherapy. Cancer Res. 1976 Jul;36(7 PT 1):2146-52. PubMed PMID: 58714.

256: Abe I, Sato S. Beta-glucuronidase activity of Yoshida ascites hepatomas of different drug-sensitivity and its change after treatment of host rats with various anticancer agents. Gann. 1976 Feb;67(1):55-65. PubMed PMID: 57896.

257: Kanamaru R, Asamura M, Sato H, Saito T. Comparative studies of effects of carbazilquinone and mitomycin C on DNA, RNA and protein synthesis of Yoshida sarcoma and Yoshida ascites hepatomas. Sci Rep Res Inst Tohoku Univ Med. 1975 Jul;22(1-2):18-24. PubMed PMID: 171766.

258: Shimizu F, Arakawa M. Effect of 3-[4-amino-2-methyl-5-pyrimidinyl)ethyl[-1(2-chloroethyl)-1-nitrosourea hydrochloride on lymphoid leukemia L-1210. Gann. 1975 Apr;66(2):149-54. PubMed PMID: 1150007.

259: Handa K, Sato S. Generation of free radicals of quinone group-containing anti-cancer chemicals in NADPH-microsome system as evidenced by initiation of sulfite oxidation. Gann. 1975 Feb;66(1):43-7. PubMed PMID: 239881.

260: Kimura NT, Kanematsu T, Baba T. Potentiation of anticancer drug effect by cancer cell glycosis: an in vitro experiment. Gann. 1974 Dec;65(6):513-22. PubMed PMID: 4464181.

261: Shindo H, Nambu K, Nakajima E, Kawai K. [Absorption, distribution, excretion and metabolism of carbazilquinone; a new anti-tumor agent, in mice (author's transl)]. Yakugaku Zasshi. 1974 Nov;94(11):1393-403. Japanese. PubMed PMID: 4478167.

262: Fukuda K, Arakawa M, Shindo H. Ultrastructural changes induced by carbazilquinone in L-1210 lymphocytic leukemia cells in mice. Gann. 1974 Aug;65(4):351-8. PubMed PMID: 4426479.

263: Nakamura T, Tatsumi K, Fukai M, Sasada M, Higuchi T. [Mode of action of carbazilquinone in leukemic cells (author's transl)]. Nippon Ketsueki Gakkai Zasshi. 1974 Apr;37(2):65-72. Japanese. PubMed PMID: 4471859.

264: Arakawa M, Okada N. Effect of carbazilquinone on leukemic cell count in various tissues of mice bearing leukemia L-1210. Gann. 1974 Feb;65(1):21-5. PubMed PMID: 4825388.

265: Saito T, Oira S, Wakui A, Yokoyama M, Takahashi H. Clinical experience with a new anticancer agent, carbazilquinone (NSC-134679). Cancer Chemother Rep. 1973 Nov-Dec;57(4):447-57. PubMed PMID: 4586952.

266: Kurita S, Nishimura M, Ogawa M, Kamei Y, Ariyoshi Y. [Clinical studies on carbazilquinone in the treatment of malignant diseases]. Nippon Gan Chiryo Gakkai Shi. 1973 Jun 20;8(2):119-27. Japanese. PubMed PMID: 4738331.

267: Arakawa M. Complete inhibition of mouse lymphoid leukemia L-1210 by carbazilquinone. Gann. 1972 Aug;63(4):487-9. PubMed PMID: 5081624.

268: Straus MJ, Goldin A. Increased lifespan using the priming dose schedule design in carbazilquinone (NSC-134679) treatment of mouse leukemia L1210. Cancer Chemother Rep. 1972 Feb;56(1):19-23. PubMed PMID: 5030804.

269: Saito T, Oira S, Wakui A, Yokoyama M, Takahashi H. [Clinical experience with a new anticancer agent, carbazilquinone]. Gan No Rinsho. 1971 Nov;17(11):806-18. Japanese. PubMed PMID: 4947602.

270: Kurita S, Nishimura M, Ogawa M, Kamei Y, Imai K. [Chemotherapy of malignant cancer using carbazilquinone]. Gan No Rinsho. 1971 Oct;17(10):744-9. Japanese. PubMed PMID: 5166829.

271: Arakawa M, Nakao H, Aoki T. Effect of carbazilquinone on transplantable and primary tumors in mice. Gann. 1970 Dec;61(6):535-9. PubMed PMID: 5499681.

272: Arakawa M, Aoki T, Nakao H. Effect of carbazilquinone on lymphoid leukemia L-1210. Gann. 1970 Oct;61(5):485-93. PubMed PMID: 5476838.